Preparation of salts of 4-4-(1R)-4-(trifluoromethyl)phenyl-2-methoxyethyl-(3S)-methyl-1-piperazinyl-4-methyl-1-(4,6-dimethyl-5-pyrimidinyl)carbonyl

摘要

In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.