PROCESS FOR THE PREPARATION OF COMPOSITIONS HAVING AN INCREASED AMOUNT OF PHARMACEUTICALLY ACTIVE SALTS OF ROTAMERS OF 4-4-(1R)-4-(TRIFLUOROMETHYL)PHENYL-2-METHOXYETHYL-(3S)-METHYL-1-PIPERAZINYL-4-METHYL-1-(4,6-DIMETHYL-5-PYRIMIDINYL)CARBONYL

摘要

In one embodiment, the present invention discloses a process to directlyprepare an unequal ratio of rotamers of an acid salt from a basic compound, bycreative choice of a solvent medium. The process is particularly useful inpreparing specific rotamers of pharmaceutically useful salts in desiredpreponderance.