Compound, acetic acid, methyl, ethyl and isopropyl esters and pharmaceutical composition

摘要

"COMPOUND, ACETIC ACID, METHYL, ETHYL AND ISOPROPYL ESTERS AND PHARMACEUTICAL COMPOSITION". The present invention relates to a compound of formula I wherein X, Y, X 39 and Y 39 are selected from the group of hydrogen, halogen, substituted or unsubstituted alkyl (linear, branched or cyclic), aryl, alkyloxy and haloalkyl; R ~ 1 ~, R ~ 2 ~, R ~ 3 ~ and R ~ 4 ~ are selected from the hydrogen group, substituted or unsubstituted alkyl (straight, branched or cyclic), aryl, heteroaryl groups, or aralkyl groups, heterocycles containing one or more of hetero atoms (ie N, S, O), substituted or unsubstituted alkenyl or alkynyl groups of 2 to 6 carbons; wherein the substituents R 1 and R 2 in the piperazinyl moiety are either sin or anti with respect to each other, and optionally R 3 and R 4 together with the carbons to which they are attached form a moiety. saturated monocyclic ring, or substituted aryl or substituted aryl or heteroaryl or substituted heteroaryl, containing one or more hetero atoms selected from N, S and 0, with a ring size ranging from 3 to 6; provided that when R3 and R4 together are not part of a ring that may exist in either the E or Z configuration; R5 is (CH ~ 2) ~ n ~ -O-CH ~ 2 ~ -CO-Z where n is 1 to 6; Z is selected from OH, OR, NRR 39, N (OR) R 39, N (R) -N (R) R 39 and where R and R 39 are selected from hydrogen, substituted or unsubstituted alkyl groups (straight, branched or cyclic), aryl, heteroaryl groups or aralkyl groups, heterocycles containing one or more of hetero atoms (ie N, S, O) substituted or unsubstituted alkenyl or alkynyl groups from 2 to 6 carbons; and B is selected from (CH ~ 2 ~) n- (n is 1 to 6) and - (CH ~ 2 ~) xD- (CH ~ 2 ~) y where D is O, NR, S or SO ~ 2, x and y are independently from 1 to 6; and m is selected from 1 to 6; and the pharmaceutically acceptable salts thereof.