Fusion partner protein, nucleic acid sequence, expression vector, host, immunogenic composition, process for preparing an immunogenic composition, process for producing a fusion protein, use of a protein or DNA sequence, and, Method To Treat A Cancer Patient

摘要

"FUSION PARTNER PROTEIN, NUCLEIC ACID SEQUENCE, EXPRESSION VECTOR, HOST, IMMUNOGENIC COMPOSITION, PROCESS FOR PREPARING AN IMMUNOGENIC COMPOSITION, PROCESS TO PRODUCE A DNA PROTEIN OR PROTEIN, , METHOD FOR TREATING A PATIENT SUFFERING FROM CANCER ". The present invention relates to fusion partners acting as immunological fusion partners, as expression enhancers, and preferably to fusion partners having both functions. In particular, fusion partners contain a so-called choline binding domain, for example fusions comprising Streptococcus pneumoniae LytA, or the pneumococcal phage lysine CP1 (CPL1) wherein the choline binding domain is modified to include a heterologous T-helper epitope, and are fused to antigens, particularly weakly immunogenic antigens such as autoantigens, e.g. ex. tumor-specific or tissue-specific antigens. The invention also relates to fusion proteins containing them, their manufacture, their use in vaccines and immunogenic compositions and their use in medicaments.