Derivatives of pyrrole Compounds, their salts, Pharmaceutical composition, Preparation Method, useful for Treating Obesity, Psychiatric Disorders, Parkinson's disease, Alzheimer's disease, immune disorders,Cardio vascular and Endocrine, Reproductive, among others.

摘要

The present invention relates to a compound of formula (I) in which RSUP1 /SUPand RSUP2 /SUPindependently represent phenyl, thienyl or pyridyl each of which is optionally substituted by one, two or three groups represented by Z; and RSUP3 /SUPis H, a CSUB1-3/SUBalkyl group, a CSUB1-3/SUBalkoxymethyl group, trifluoromethyl, a hydroxyCSUB1-3/SUBalkyl group, an aminoCSUB1-3/SUBalkyl group, CSUB1-3/SUBalkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di CSUB1-3/SUBalkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula -CONHNRSUPa/SUPRSUPb /SUPwherein RSUPa /SUPand RSUPb /SUPare as defined for RSUP4 /SUPand RSUP5 /SUPrespectively; X is CO or SOSUB2/SUB; Y is absent or represents NH optionally substituted by a CSUB1-3/SUBalkyl group; RSUP4 /SUPand RSUP5 /SUPindependently represent: a CSUB1-6/SUBalkyl group; an (amino)CSUB1-4/SUBalkyl-group in which the amino is optionally substituted by one or more CSUB1-3/SUBalkyl groups; an optionally substituted non-aromatic CSUB3-15/SUBcarbocyclic group; a (CSUB3-12/SUBcycloalkyl)CSUB1-3/SUBalkyl-group; a group -(CHSUB2/SUB)SUBr/SUB(phenyl)SUBs/SUB; naphthyl; anthracenyl; a saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen wherein the heterocyclic group is optionally substituted; 1-adamantylmethyl; a group -(CHSUB2/SUB)SUBt /SUBHet where Het represents an aromatic heterocycle optionally substituted; or RSUP4 /SUPrepresents H and RSUP5 /SUPis as defined above; or RSUP4 /SUPand RSUP5 /SUPtogether with the nitrogen atom to which they are attached represent a saturated 5 to 8 membered heterocyclic group; RSUP6 /SUPis H, a CSUB1-3/SUBalkyl group, a CSUB1-3/SUBalkoxymethyl group, trifluoromethyl, a hydroxyCSUB1-3/SUBalkyl group, CSUB1-3/SUBalkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di CSUB1-3/SUBalkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula -CONHNRSUPa/SUPRSUPb/SUP; with provisos; to processes for preparing such compounds, to their use in the treatment of obesity, psychiatric and neurological disorders particularly obesity, to methods for their therapeutic use and to pharmaceutical compositions containing them.