首页> 外国专利> Derivatives of Benzothiazole compounds substituted with Dioxane, adenosine receptor ligands with Affinity with A2A receptors.A1 and A3; Pharmaceutical composition, Preparation method and use of the compounds in the treatment of re

Derivatives of Benzothiazole compounds substituted with Dioxane, adenosine receptor ligands with Affinity with A2A receptors.A1 and A3; Pharmaceutical composition, Preparation method and use of the compounds in the treatment of re

机译:被二恶烷取代的苯并噻唑化合物的衍生物,与A2A受体具有亲和力的腺苷受体配体.A1和A3;药物组合物,该化合物的制备方法和在再治疗中的用途

摘要

The present invention relates to compounds of the general formula Iwherein R1, R2, R', R'', n, m and o are defined herein, or a pharmaceutically acceptable salt thereof.It has been found that the compounds of general formula I are adenosine receptor ligands with a good affinity to the A2A-receptor and a high selectivity to the A1- and A3 receptors. These compounds have useful pharmacological activities.
机译:本发明涉及通式I的化合物或其药学上可接受的盐,其中R 1,R 2,R',R'',n,m和o在本文中定义。通式I的化合物是对A2A受体具有良好亲和力且对A1和A3受体具有高选择性的腺苷受体配体。这些化合物具有有用的药理活性。

著录项

  • 公开/公告号CL2004000761A1

    专利类型

  • 公开/公告日2005-02-04

    原文格式PDF

  • 申请/专利权人 F. HOFFMANN-LA ROCHE AG.;

    申请/专利号CL20040000761

  • 发明设计人 ROGER DAVID NORCROSS;

    申请日2004-04-08

  • 分类号A61K31/428;A61P25/00;C07D207/34;C07D277/82;C07D319/12;C07D417/04;

  • 国家 CL

  • 入库时间 2022-08-21 22:18:22

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