Compounds derived from Aniline.Agonists of the peroxisome proliferator Activator receptors (PPAR); Process for their preparation, Pharmaceutical compositions, and use in Diseases Modulated by PPAR Delta agonists and / orPPAR alpha, d

摘要

This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; RSUP1 /SUPis hydrogen or CSUB1-7/SUB-alkyl; RSUP2 /SUPand RSUP3 /SUPindependently from each other are selected from the group consisting of hydrogen, CSUB1-7/SUB-alkyl and CSUB1-7/SUB-alkoxy; RSUP4/SUP, RSUP5/SUP, RSUP6/SUP, and RSUP7 /SUPindependently from each other are selected from the group consisting of hydrogen, CSUB1-7/SUB-alkyl, CSUB3-7/SUB-cycloalkyl, halogen, CSUB1-7/SUB-alkoxy, CSUB1-7/SUB-alkyl-CSUB1-7/SUB-alkoxy-CSUB1-7/SUB-alkyl, CSUB2-7/SUB-alkenyl, CSUB2-7/SUB-alkinyl, fluoro-CSUB1-7/SUB-alkyl and cyano; RSUP8 /SUPis selected from the group consisting of hydrogen, CSUB1-7/SUB-alkyl, CSUB3-7/SUB-cycloalkyl and fluoro-CSUB1-7/SUB-alkyl; RSUP9 /SUPis selected from the group consisting of hydrogen, CSUB1-7/SUB-alkyl, CSUB2-7/SUB-alkinyl, CSUB3-7/SUB-cycloalkyl and fluoro-CSUB1-7/SUB-alkyl; RSUP10 /SUPis selected from the group consisting of hydrogen, CSUB1-7/SUB-alkyl, CSUB2-7/SUB-alkinyl, CSUB3-7/SUB-cycloalkyl and fluoro-CSUB1-7/SUB-alkyl; RSUP11 /SUPis aryl or heteroaryl; N is 0, 1 or 2; and all enantiomers and pharmaceutically acceptable salts and/or esters thereof and their use as PPAR activators.