AN EFFICIENT SYNTHESIS OF 5-HETEROATOM-CONTAINING-PYRAZOLES.

摘要

An efficient synthesis of sulfonyl pyrazoles of formula (I), wherein the ring of the formula (R5)-A-(SOmR4), m, R1 through R9 are as defined in the specification, comprising reacting a compound of formula (II), wherein the ring of the formula (R5)-A-(SOmR4), m R1 through R9 are as defined above and wherein R10 is halo, (C1-C6)alkyl-SO3-, (C6-C10)aryl-SO3-, (C1-C6)alkyl-SO2-, or (C6-C10)aryl-SO2-; wherein each of said (C1-C6)alkyl component of said (C1-C6)alkyl- SO3- and (C1-C6)alkyl-SO2- radicals may optionally be substituted on any carbon atom by one to six fluoro substituents per (C1-C6)alkyl component; with a compound of formula R3-H, wherein R3 is as defined above, in the presence of a fluoride containing salt and in the presence of a solvent.