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A pharmaceutical composition comprising a sulphonated meso-tetraphenyl chlorin as a photosensistizing agent for use in photodynamic therapy
A pharmaceutical composition comprising a sulphonated meso-tetraphenyl chlorin as a photosensistizing agent for use in photodynamic therapy
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机译:用于光动力疗法的药物组合物,其包含磺化的中四苯基二氢卟酚作为光分解剂
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摘要
Photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin are described, particularly a disulphonated meso-tetraphenylporphyrin such as TPPS2a. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula (I) (wherein X is -SO3H; n, p, q and r are each independently 0 or 1; and the sum of n, p, q and r is an integer from 1 to 4, isomers and isomer mixtures thereof. The compounds described and their pharmaceutically acceptable salts have particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy.
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