Isoflurane derivatives as sodium glucose transmitter inhibitors

摘要

It refers to a compound made of a formula of heterocyclic fluorescent derivative, in which R1 and R2 are f, h or one of them is oh; R3 is Oh or F, at least one of R1, R2 or R3 is f; R4 is oh; a is O, NH, CH2, s or link; x is C, O, s or N, when x is C or s, X should be C; y is n, or s; or N, or s, M is 1 or 2; R5 is h, F, Cl, Br, 1. Oh, phenyl, CF3, CN, CO (tar (C1-C6),R6 is, among other things, h, asphalt (C1-C6),Alquenio（C1-C6），1. Cyclopentyl (C3-C6) or phenyl which can be replaced by halogen or asphalt (C1-C4);Or when y is s, R5 and R6, they are combined to be phenyl; B is alkane (c0-c15), where one or more C can be formed by - or--C (=O)-CH=CH--- yes.-Ch (OH)Among others, n is 0-4; Cyc1 is a 3-7 ring, which is saturated or unsaturated in whole or in part, where C can be replaced by O, n or s; R7, R8 and R9 are f, Cl, Br, I, oh, CF3, NO2, CN, etc.; or R8 and R9 are added together to form a 5-7 C2 ring, Full or partial saturation or unsaturated also refers to the preparation procedure These compounds are inhibitors of sodium based glucose carriers and can be used in combination with at least one glucose reducing agent for the treatment of type 1 and type 2 diabetes.