NEW PROCEDURE FOR SYNTHESIS OF THE ACID (2S, 3AS, 7AS) PERHYDROINDOL-2-CARBOXYL AND ITS ESTERS, AND APPLICATION AS THE SYNTHESIS OF PERINDOPRIL.

摘要

Synthesis process of compounds of ** formula ** in which R represents a hydrogen atom or a linear or branched benzyl or alkyl group of 1 to 6 carbons, characterized in that a protected (L) -serine condensate is condensed, in which R1 represents a linear or branched alkyl group of 1 to 6 carbons or a benzyl, and in which Ar represents either a phenyl group optionally substituted with one or more alkyl groups of 1 to 6 linear or branched carbons, or a naphthyl group , in which the amino function is deprotected and, when desired, the acid function, to lead to the compound of formula (I).