VACCINES AGAINST AUJESZKY'S DISEASE AND OTHER ANIMAL DISEASES CONTAINING PSEUDORABIES VIRUS MUTANTS

摘要

The invention provides vaccines for preventing and controlling animaldiseases, comprising a pseudorabies virus containingglycoprotein gp50 and having a mutation in its gp50 gene. The vaccines aresuitable for use against Aujeszky's disease (pseudorabies),or against other animal diseases when the mutation is an insertion comprisinga heterologous gene encoding an antigencorresponding to said animal disease. The pseudorabies virus may additionallyhave at least one mutation in one of its othergenes, such as the gp63 gene or the g1 gene. The vaccines are unable to spreadfrom vaccinated to non-vaccinated animals.