NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES

摘要

The present invention is relatedto novel intermediates and processeswhich are useful in the preparationof certain antihistaminic piperidinederivatives of formula (I) wherein Wrepresents -C(=O)- or -CH(OH)-; R1represents hydrogen or hydroxy; R2represents hydrogen; R1 and R2 takentogether form a second bond betweenthe carbon atoms bearing R1 and R2;n is an integer of from 1 to 5; m isan integer 0 or 1; R3 is -COOH or-COOalkyl wherein the alkyl moietyhas from 1 to 6 carbon atoms and isstraight or branched; each of A is hydrogen or hydroxy; and pharmaceuticallyacceptable salts and individual optical isomers thereof, withthe proviso that where R1 and R2 are taken together to form a second bondbetween the carbon atoms bearing R1 and R2 or where R1represented hydroxy, m is an integer 0.