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NOVEL CRYSTALLINE POLYMORPHS OF CLOPIDOGREL

机译:新颖的氯多酚晶体

摘要

The present invention relates to novel crystalline forms of the plateletaggregation inhibitor(+)-(S)-methyl-2-(2-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate, clopidogrel (1), in the formof hydrogen bromide salts, identified as polymorph forms 1, 2 and 3. Thepresent invention furtherrelates to processes for preparing such forms, pharmaceutical compositionscomprising such forms,and uses for such forms and compositions. The pharmaceutical compositions maybe used, inparticular, for inhibiting platelet aggregation or for treating, preventing ormanaging thrombosis,atherothrombosis, an atherothrombotic event, ischaemic stroke, myocardialinfarction, non-Q-wavemyocardial infarction, atherosclerosis, peripheral arterial disease, orunstable angina. The presentinvention also relates to methods of treating said disorders.(see formula 1)
机译:本发明涉及血小板的新型晶体形式聚集抑制剂(+)-(S)-甲基-2-(2-氯苯基)-6,7-二氢-4H-噻吩并[3,2-c]吡啶-5-醋酸氯吡格雷(1)的形式的溴化氢盐,确定为多晶型物1、2和3。本发明进一步涉及制备此类形式的方法,药物组合物包含此类表格,以及此类形式和组合物的用途。药物组合物可以用在特别是用于抑制血小板凝集或治疗,预防或处理血栓动脉粥样硬化血栓形成,动脉粥样硬化血栓形成事件,缺血性中风,心肌梗死,非Q波心肌梗塞,动脉粥样硬化,外周动脉疾病或不稳定型心绞痛。现在本发明还涉及治疗所述疾病的方法。(请参见公式1)

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