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EVALUATION METHOD FOR PREDICTING PHARMACOKINETICS OF PM USING PM LIVER CELLS OF DRUG METABOLIZING ENZYME CYTOCHROME P450 HAVING A GENETIC POLYMORPHISM
EVALUATION METHOD FOR PREDICTING PHARMACOKINETICS OF PM USING PM LIVER CELLS OF DRUG METABOLIZING ENZYME CYTOCHROME P450 HAVING A GENETIC POLYMORPHISM
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机译:利用遗传多态性的药物代谢细胞色素P450的PM肝细胞预测PM的药动学评价方法。
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摘要
There is provided a novel evaluation method for predicting the pharmacokinetics of PM using PM liver cells of drug metabolizing enzyme cytochrome P450 having a genetic polymorphism. According to the present invention, the pharmacokinetics (metabolism) of PM can be predicted by using PM liver cells of CYP2D6 among drug metabolizing enzyme cytochrome P450 known to have a genetic polymorphism.
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