Isomerisation of 6beta-fluorosteroids into the corresponding 6alpha-fluoro derivatives

摘要

Described herein is the isomerisation process of 6 beta -fluorosteroids into the corresponding pharmacologically active 6 alpha -fluoro derivatives, comprising the reaction of 6 beta -fluorosteroids, or 6 alpha /6 beta isomeric mixtures, with an organic base containing a diazoimino group in a suitable organic solvent.