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INHERITED DEFORMITY OF HINDLIMB MOUSE AND METHOD FOR PRODUCING THE SAME, WHICH HAS CLUB FOOT DERIVED USING CHEMICAL MATERIAL
INHERITED DEFORMITY OF HINDLIMB MOUSE AND METHOD FOR PRODUCING THE SAME, WHICH HAS CLUB FOOT DERIVED USING CHEMICAL MATERIAL
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机译:腿肢的固有畸形及其制造方法(使用化学材料衍生出脚趾)
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摘要
PURPOSE: An inherited deformity of a hindlimb mouse which has a club foot derived using a chemical material, ENU(N-ethyl-N-nitrosourea) and method for producing the same are provided. CONSTITUTION: The inherited deformity of the hindlimb mouse has the club foot derived using the ENU. The mouse is prepared by a random mutagenesis. The method for producing the same comprises the steps of: inducing a mutation by inputting ENU to a male mouse; producing 3-generation mouse by crossing the mouse having the mutation with a normal mouse, crossing an obtained 1-generation mouse with a normal mouse and backcrossing an obtained 2-generation mouse with the 1-generation mouse; and screening a mouse having the club foot symptom from the 3-generation mouse.
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