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Inherited deformity of the hindlimb mouse and method for producing the same
Inherited deformity of the hindlimb mouse and method for producing the same
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机译:后肢小鼠的遗传畸形及其产生方法
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摘要
PURPOSE: An inherited deformity of a hindlimb mouse which has a club foot derived using a chemical material, ENU(N-ethyl-N-nitrosourea) and method for producing the same are provided. CONSTITUTION: The inherited deformity of the hindlimb mouse has the club foot derived using the ENU. The mouse is prepared by a random mutagenesis. The method for producing the same comprises the steps of: inducing a mutation by inputting ENU to a male mouse; producing 3-generation mouse by crossing the mouse having the mutation with a normal mouse, crossing an obtained 1-generation mouse with a normal mouse and backcrossing an obtained 2-generation mouse with the 1-generation mouse; and screening a mouse having the club foot symptom from the 3-generation mouse.
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