METHOD FOR TREATMENT OF NEURODEGENARATIVE DISEASES BY ADMINISTERING COMPOUNDS WHICH PROTECT NEURONAL CELLS FROM CELL CYTOTOXICITY DUE TO VARIOUS NEURONAL TOXIC SUBSTANCES

摘要

PURPOSE: A method for treatment of neurodegenarative diseases using compounds is provided, which compounds protect neuronal cells from the cell cytotoxicity due to various neuronal toxic substances. CONSTITUTION: The method for treatment of neurodegenarative diseases comprising administering compounds represented by formula (1) into an object, wherein A is H, R or (CH2)n-Ar3-R5R6; Ar1, Ar2 and Ar3 are independently phenyl, thienyl, furyl or pyrrolyl; R1, R2, R3, R4, R5 and R6 are independently H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR', ROH, ROR', RSH, RSR', RO(CO)R'OH, NHR, NRR', RNHR' or RNR'R", or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; R, R' and R" are independently C1-C6 alkyl; n is 1, 2 or 3; and the neurodegenarative disease is Parkinson's disease, Huntington's disease or Alzheimer's disease.