COLLYBIA CONFLUENS EXO-BIOPOLYMER HAVING A HYPOGLYCEMIC ACTIVITY WHICH IS PRODUCED FROM SUBMERGED MYCELIAL CULTURE, A METHOD FOR ISOLATION OF SAID EXO-BIOPOLYMER AND A THERAPEUTICAL COMPOSION FOR DIABETES THEREOF

摘要

The present invention relates to a method that separate the outer of cells derived polysaccharide, wheat mushrooms (Collybia confluens) having a hypoglycemic effect and as it relates to a composition for treating diabetes comprising as an active ingredient, mushroom mill using streptozotocin toxin-induced diabetic rats an extracellular polysaccharide produced from the mycelium liquid culture of the decreases in plasma glucose concentrations as compared to diabetic control group dependent on the concentration of the extracellular polysaccharide, in particular extracellular polysaccharide 150 mg / kg of body weight decreased by 29.3% in the plasma glucose concentration in there is an excellent effect. Further, the total cholesterol, tri-glycerides, alanine transaminase, and the effect of lowering the rate aspartate transaminase concentration of 23.3, 30.7, 34.6, and 23.6%, respectively, of the plasma. An extracellular polysaccharide of the present invention wheat mushroom stems having a hypoglycemic effect is a glycoprotein consisting of 83.19% sugar and proteins of 16.81%, the major sugar is formed of only the nose and glucosidase Woods, key amino acids are serine, glycine and it consists of alanine. Therefore, an extracellular polysaccharide of the present invention provides wheat that is derived from mushroom, so the hypoglycemic effect it is possible to provide for an excellent diabetic treatment compositions containing them as the active ingredient is extremely useful inventions the pharmaceutical industry.