METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING

摘要

A method for deuteration or tritiation of a heterocyclic ring, characterized in that it comprises allowing a heterocyclic compound to be present under a sealing and refluxing condition in a deuterated or tritiated solvent in the presence of an activated catalyst selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. The method allows a deuteration or tritiation temperature to be kept at a temperature higher than the boiling temperature of the solvent, which results in the replacement of a hydrogen atom in a heterocyclic ring of a heterocyclic compound with very good efficiency. Further, the method can be widely used for the deuteration or tritiation of various types of heterocyclic compounds being decomposed under a supercritical condition or an acidic condition, and thus can be used for efficient deuteration or tritiation of a heterocyclic compound in a commercial process.