Use of gum arabic as an active agent in cosmetic and dermatological compositions, useful particularly for treatment and prevention of ageing of the skin

摘要

Use of gum arabic (A) as a cosmetic and dermatological active agent. ACTIVITY : Dermatological. MECHANISM OF ACTION : Fibroblast proliferation stimulator; collagen synthesis stimulator. Normal human skin fibroblasts were grown as monolayers for 24 hours, then treated with 0.5 % gum arabic for 1-6 days, then cell viability determined by measuring mitochondrial dehydrogenases (conversion of methylthiazol tetrazolium). For young fibroblasts (4th passage), the percentage viability after 6 days was 0 % for a negative control; 104 % for a positive control and 24 % for cells treated with gum arabic. For older cells (8th passage), gum arabic was effective more quickly and viability was 34 % after 1 day.