METHOD FOR DETECTING BASE POLYMORPHISMS OF EFFECTIVENESS-DIAGNOSIS GENE IN METHOTREXATE THERAPY FOR ARTHRORHEUMATISM PATIENT

摘要

PPROBLEM TO BE SOLVED: To provide a method for deciding effectiveness of methotrexate therapy for an arthrorheumatism patient, and to provide a kit therefor. PSOLUTION: The method for deciding effect and dose of methotrexate for the arthrorheumatism patient is characterized by detecting base polymorphisms (SNP) of 3435th base of exon 26 of ABCB1 gene, and the kit for deciding effectiveness of methotrexate therapy, containing primer capable of amplifying regions containing polymorphism part corresponding to 3435th of exon 26 of ABCB1 gene, is provided. PCOPYRIGHT: (C)2006,JPO&NCIPI