Microemulsion concentrate for oral administration of poorly soluble cold medicine and method for producing the same

摘要

A microemulsion concentrate comprising a water-insoluble anti-cold drug, a surfactant and an oil, which is prepared by a method comprising: (a) dissolving the water-insoluble anti-cold drug in a co-surfactant to obtain a homogeneous drug solution; (b) adding the surfactant and the oil in the drug solution to obtain a microemulsion pre-concentrate; and (c) removing the co-surfactant from the pre-concentrate, contains emulsified drug microparticles which are stable toward pH change and therefore, provides improved bioavaiability of the drug when orally administered.