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Methods and compositions for screening for modulators of neuronal cell death in Parkinson's disease
Methods and compositions for screening for modulators of neuronal cell death in Parkinson's disease
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机译:筛选帕金森氏病中神经元细胞死亡调节剂的方法和组合物
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摘要
Methods and compositions for identifying an agent (e.g., a gene product or small molecule compound that modulates neuronal cell death in a Parkinson's disease animal model are provided. In practicing the subject methods, a non-mammalian animal model, such as Drosophila melanogaster, that includes a mutant parkin gene and at least one other mutant gene are evaluated for neuronal cell death. Also provided are kits and systems for practicing the subject methods, as well as methods of use of agents identified in the screening method of the invention.
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