A device for the transcutaneous administration of substances by means of iontophoresis comprises an operative head (1) provided with an inlet (2) for a fluid transporting substances to be administered, with a dispenser (3) of the fluid which has a part (30) in contact with the skin, with an electrode (4) positioned on a path of the fluid from the inlet (2) to the dispenser (3). The dispenser (3) is made of an electrically conducting material and it is in electrical contact with the electrode (4) only by the action of the fluid. The dispenser (3) and the electrode (4) are arranged in a predetermined relative position which maintains constant over time the geometric shape of the volume of fluid present between them.
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