Therapeutical composition containing monoclonal antibody anti-CD154 or a derivative thereof for treating exogenous protein inhibitor syndrome

摘要

In the present invention, there are disclosed methods and compositions used for attenuating or mitigating; suppressing; preventing; delaying onset of; or, reversing exogenous protein inhibitor syndrome, exemplified by clotting factor (e.g., factor VIII) inhibitor syndrome. The described methods use a CD40:CD154 binding interruptor, such as CD154 blocking agent, to attenuate or ameliorate counter-adaptive, bioinhibitory humoral immunity directed against an exogenous protein of therapeutic value. In particular, the invention relates to the use of a monoclonal antibody anti-CD154 or a derivative thereof for the preparation of a medicament intended for the treatment of exogenous protein inhibitor syndrome in a patient suffering from or endangered with this kind of syndrome.