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PROCESS FOR PRODUCING MOULDINGS FROM (METH) ACRYLATE COPOLYMERS BY MEANS OF INJECTION MOULDING

机译:通过注射成型的方法从(甲基)丙烯酸酯共聚物生产模具的方法

摘要

The invention relates to a method for producing moulded bodies by means of injection moulding, comprising the following steps: a) a (meth)acrylate copolymer, consisting of between 85 and 98 wt. % of radically polymerised C1 to C4 alkyl esters of the acrylic or methacrylic acid and between 15 and 2 wt. % of (meth)acrylate monomers having a quaternary ammonium group in the alkyl radical, is melted and mixed with between 10 and 25 wt. % of a plasticizer, between 10 and 50 wt. % of an anti-adhesive agent, and/or between 0.1 and 3 wt. % of a parting agent, and optionally other pharmaceutically standard additives or auxiliary agents and/or a pharmaceutical active ingredient; b) the mixture is degassed at temperatures of at least 120 °C, whereby the content of low-boiling constituents is reduced to, at the highest, 0.5 wt. %, with a steam pressure of at least 1.9 bar at 120 °C; and c) the degassed mixture is injected at a temperature of between 80 and 160 °C in the mould of an injection moulding unit and the moulded body obtained is removed from the mould.
机译:本发明涉及通过注射成型生产模制体的方法,其包括以下步骤:a)由85至98重量%的(甲基)丙烯酸酯共聚物组成。丙烯酸或甲基丙烯酸的自由基聚合的C 1 -C 4烷基酯的重量百分比,在15和2wt。 %的在烷基中具有季铵基的(甲基)丙烯酸酯单体被熔融并与10-25wt。%之间混合。增塑剂的10%,介于10至50 wt。 %的抗粘剂,和/或0.1至3wt%。脱模剂和任选的其他药学上标准的添加剂或辅助剂和/或药物活性成分的百分比; b)将混合物在至少120°C的温度下脱气,从而使低沸点成分的含量最高降低至0.5 wt%。 %,在120°C时蒸汽压至少为1.9 bar; c)将脱气的混合物在80至160℃之间的温度下注射到注射模制单元的模具中,并将获得的成型体从模具中取出。

著录项

  • 公开/公告号IL153650B

    专利类型

  • 公开/公告日2006-01-15

    原文格式PDF

  • 申请/专利权人 GLAXO GROUP LIMITED;EVONIK ROHM GMBH;

    申请/专利号IL153650

  • 发明设计人

    申请日2002-12-25

  • 分类号

  • 国家 IL

  • 入库时间 2022-08-21 21:39:11

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