VACCINE COMPRISING AN ANGIOMOTIN OR A POLYNUCLEOTIDE ENCODING AN ANGIOMOTIN AND ITS USES FOR THE TREATMENT OF ANGIOGENIC-RELATED DISORDERS

摘要

A vaccine for preventing formation of blood vessels, for example neoangiogenesis, as well as repressing existing vascularization associated with tumors and other diseases, comprising angiomotin, for example as a whole molecule or fragment thereof or encoded as a gene or mRNA, or administered as dendritic cells (DC cells) expressing angiomotin, which may be utilized to generate immune responses to the angiomotin molecule. Inhibition of angiogenesis and delay in tumor outgrowth in animal models of cancer is achieved.