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An isolated human monoclonal antibody that binds to human epidermal growth factor receptor (EGFR)
An isolated human monoclonal antibody that binds to human epidermal growth factor receptor (EGFR)
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机译:与人表皮生长因子受体(EGFR)结合的分离的人单克隆抗体
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摘要
An isolated human monoclonal antibody which binds to human EGFR on the same epitope on EGFR as an antibody comprising a heavy chain variable region having the amino acid sequence in SEQ ID NO:2 and a light chain variable region having the amino acid sequence in SEQ ID NO:4. The human antibody blocks EGFR ligand binding to human EGFR and can be used in the manufacture of a medicament for treating or preventing a disease mediated by expression of EGFR.
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机译:分离的人单克隆抗体,其与包含具有SEQ ID NO:2的氨基酸序列的重链可变区和具有SEQ ID NO:2的氨基酸序列的轻链可变区的抗体在EGFR相同表位上结合人EGFR否:4。人抗体阻断EGFR配体与人EGFR的结合,并可用于制备用于治疗或预防由EGFR表达介导的疾病的药物。
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