PHARMACEUTICAL COMPOUNDS FOR STIMULATION OF ANGIOGENESIS (VARIANTS), PHARMACEUTICAL COMPOUNDS FOR INHIBITION OF ANGIOGENESIS (VARIANTS) AND METHOD FOR MODULATING ANGIOGENESIS USING THESE COMPOUNDS

摘要

The invention relates to the pharmaceutical compounds for stimulation of angiogenesis containing viral or non-viral expression vector coding for active Src-protein (tyrosine kinase). The coding protein contains any amino acid at codon 527 except for tyrosine, serine, or threonine. The invention also relates to the pharmaceutical compounds for inhibition of angiogenesis containing viral or non-viral expression vector coding for inactive Src-protein lacking kinase activity (Src 251 or К295М protein). The method for modulating angiogenesis using the pharmaceutical compounds indicated above is also provided.