Compound, medicament, pharmaceutical composition, method for preventing or treating a disease against which gene expression control is effective, method for preventing or treating a disease for which vegf production suppression is effective, method for preventing or treating a disease against which an inhibition of angiogenesis is effective, use of the compound, method to produce a 9-deoxy 1107 compound, streptomyces sp. a-1543 (ferm bp-8442), method of producing a 6-deoxy compound, and a-1544 strain (ferm bp-8446) or a-1545 strain (ferm bp-8447)

摘要

"COMPOSITION, MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION, METHOD FOR PREVENTING OR TREATING A DISEASE FOR WHICH A GENE EXPRESSION CONTROL IS EFFECTIVE, METHOD FOR PREVENTING OR TREATING A DISEASE FOR WHICH THE SUPPRESSION OF VEGFRE PRODUCTION IS EFFECTIVE, A DISEASE WHICH AN ANGIOGENESIS INHIBITION IS EFFECTIVE, USE OF THE COMPOUND, METHOD TO PRODUCE A 6-DEOXI 1107 COMPOUND STREPTOMYCES LINE (FERM BP-8442), METHOD TO PRODUCE A 6-DEXI A-1544 LINE (FERM BP-8446) OR A-1545 LINE (FERM BP-8447) ". Compounds represented by the following general formula (I), their pharmacologically acceptable salts or hydrates thereof: (I) where W represents and R 3, R 7, R 16, R 17, R 20 , R ^ 21 ^ and R ^ 21 39 ^ are the same or different and each represents hydrogen, etc. Because they inhibit angiogenesis and inhibit VEGF production particularly in hypoxia, compounds (I) are useful as solid cancer remedies.