DERIVATIVES OF 4-AMINOTIAZOL, ITS PREPARATION AND ITS USE AS INHIBITORS OF CYCLINE DEPENDENT KINASE

摘要

A compound of Formula I: in which: R 1 is a substituted or unsubstituted group selected from C 1-6 alkyl, C 1-6 alkenyl; C1-6 alkynyl; C1-6 alkoxy, C1-6 alcohol, carbocyclic or heterocyclic, monocyclic or polycyclic condensed or non-condensed cycloalkyl, carbocyclic or heterocyclic aryl, monocyclic or non-condensed polycyclic, naphthyl, indolyl, quinolinyl, isoquinolinyl, acridinyl, benzimidazolyl, benzothiophenyl, benzothiophenyl carbonyl, ether, (C1-6 alkyl) -carbonyl, (C1-6 alkyl) aryl, (C1-6 alkyl) -cycloalkyl, (C1-6 alkyl) - (C1-6 alkoxy); aryl- (C1-6 alkoxy), thioether, thiol, and sulfonyl, where when R1 is substituted, each substituent is independently halogen, haloalkyl, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, hydroxyl, C1- alkoxy 6, amino, nitro, thiol, thioether, imine, cyano, amido, phosphonate, phosphine, carboxyl, thiocarbonyl, sulfonyl, sulfonamide, ketone, aldehyde, ester, oxygen, carbocyclic or heterocyclic cycloalkyl, condensed or non-condensed monocyclic or carbocyclic aryl or heterocyclic, monocyclic or condensed or non-condensed polycyclic and R2 is a condensed or non-condensed carbocyclic or heterocyclic, monocyclic or polycyclic ring structure having a substituent in the position adjacent to the junction point, whose ring structure is further optionally substituted, where each R2 substituent is independently halogen, haloalkyl, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, hydroxyl, C1-6 alkoxy, amino, nitro, thiol, t ioether, imine, cyano, amido, phosphonate, phosphine, carboxyl, thiocarbonyl, sulfonyl, sulfonamide, ketone, aldehyde, ester, oxygen, carbocyclic or heterocyclic, monocyclic or polycyclic condensed or non-condensed cycloalkyl or carbocyclic or heterocyclic, monocyclic or condensed monocyclic or non-condensed, or a pharmaceutically acceptable salt of a compound of Formula I, or pharmaceutically acceptable salt thereof.