SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY

摘要

Compounds representedby formula (I), are disclosed.AR represents an aromaticgroup containing 6-10 atoms;and (a) represents a 4 tomembered non-aromaticheterocycle containing at leastone N atom, and optionallycontaining 1-2 additional Natoms and 0-1 O or S atom.A pharmaceutical compositionis also included. Methods oftreating cancer and cytokinemediated diseases are alsoincluded.