5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione derivatives, as inhibitors of zinc metallondopeptidases, their preparation and use.

摘要

New Pyrimidinetrione derivatives represented by formula Iwherein R1 and R2 are defined in the description, composition thereof, and methods of preparation are described.;The compounds are useful in the treatment of disease involving metalloproteinases