ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

摘要

A compound of formula (I) :(whereinR¹-R¹⁰ are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X¹ is -O-, -S-, -NR¹¹- (wherein R¹¹ is hydrogen, lower alkyl or the like), -CR¹²R¹³CO-, -(CR¹²R¹³)mO-, -O(CR¹²R¹³)m- (wherein R¹² and R¹³ are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like,X² is a bond, -O-, -S-, -NR¹⁴- (wherein R¹⁴ is hydrogen, lower alkyl or the like, R¹⁴ and R⁶ can be taken together with the neighboring atom to form a ring) or -CR¹⁵R^16-(wherein R¹⁵ and R¹⁶ are each independently hydrogen or lower alkyl, R¹⁵ and R⁶ or R¹⁰ can be taken together with the neighboring carbon atom to form a ring, R¹⁶ and R⁹ can be joined together to form a bond), X³ is COOR¹⁷, C( = NR¹⁷)NR¹⁸OR¹⁹ or the like), a pharmaceutically acceptable salt or a solvate thereof.