ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

摘要

A compound of formula (I) : (wherein R 1 -R 10 are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X 1 is -O-, -S-, -NR 11 - (wherein R 11 is hydrogen, lower alkyl or the like), -CR 12 R 13 CO-, -(CR 12 R 13 )mO-, -O(CR 12 R 13 )m- (wherein R 12 and R 13 are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X 2 is a bond, -O-, -S-, -NR 14 - (wherein R 14 is hydrogen, lower alkyl or the like, R 14 and R 6 can be taken together with the neighboring atom to form a ring) or -CR 15 R 16- (wherein R 15 and R 16 are each independently hydrogen or lower alkyl, R 15 and R 6 or R 10 can be taken together with the neighboring carbon atom to form a ring, R 16 and R 9 can be joined together to form a bond), X 3 is COOR 17 , C( = NR 17 )NR 18 OR 19 or the like), a pharmaceutically acceptable salt or a solvate thereof.