METHOD FOR PRODUCING ENANTIOMERIC PURE PROFENS USING THE RACEMIZATION AND CHIRAL RESOLUTION

摘要

The present invention La that interconnects the optical resolution reaction using racemization and biocatalysis using a chemical catalyst in a reaction system using as chemical catalyst to a method of producing optically pure form of the pro penryu in US process and the stability at high temperature and pure pro penryu a combination of the optical resolution process using a biological catalyst of hyperthermophilic enzymes exhibit optimal activity optically by using the (Dynamic Kinetic Resolution) DKR process for to take place in a reaction system yields It provides a method of production that can be obtained with. As described above, the present invention can be carried out at a high total DKR process temperature by the use of a hyperthermophilic enzyme to a biological catalyst La by faster US response time improves the yield and optical purity of the final product, and a conventional chemical this provides a significant reduction in the production method of the environment-friendly procedure penryu use of an organic solvent compared to the process. ; Businesses penryu, chemical catalysts, biological catalysts, enzymes hyperthermophilic