Molecular resonant tunneling sensor and methods of fabricating and using the same

摘要

Resonant tunneling devices and methods of using and fabricating the same are provided. The subject devices include a first 110 and second 111 fluid containment members separated by a fluid barrier 109 having a single nanopore 101 therein providing fluid communication between the first and second fluid containment members, wherein the nanopore 101 has a top inner diameter that is smaller than a bottom inner diameter and includes first 107 and second 105 perimeter electrodes separated by an insulator element 106, and a proteinaceous channel 102 positioned in the nanopore. Also provided are methods of fabricating such a device and methods of using such a device for improved detection and characterization of a sample.