首页> 外国专利> Method for enhancing cell sensitization by preceding treatment of methylglyoxal-bisguanylhydrazone on ?-radiation-induced cell death

Method for enhancing cell sensitization by preceding treatment of methylglyoxal-bisguanylhydrazone on ?-radiation-induced cell death

机译:预先处理甲基乙二醛-双胍hydr对γ射线诱导的细胞死亡的增强细胞敏感性的方法

摘要

The present invention relates to a method tumor cell death, and more particularly, methyl glyoxal in the tumor cell line-bis (not obtain hydrazone) and then pre-processing the (MGBG), the gamma irradiation in G1 phase of the cell cycle by S group relates to an apoptosis through the way of the movement inhibiting or G2 group. According to the invention, use makes a movement in the G1 phase of the cell S phase or G2 groups useful for the opportunity to repair cell damage caused by the gamma radiation or the like block by maximizing the apoptotic effect in tumor cell lines in a short time leukemia by It can be.
机译:本发明涉及一种肿瘤细胞死亡的方法,更具体地,涉及肿瘤细胞系-bis(未获得)中的甲基乙二醛,然后预处理(MGBG),通过S基团通过运动抑制或G2基团的方式与细胞凋亡有关。根据本发明,利用使细胞S期或G2基团的G1期运动对于通过短期内最大化肿瘤细胞系的凋亡效应来修复由γ射线或类似物阻断引起的细胞损伤的机会是有用的。可以按时间白血病。

著录项

  • 公开/公告号KR100542877B1

    专利类型

  • 公开/公告日2006-01-20

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20030075429

  • 申请日2003-10-28

  • 分类号A61K31/175;

  • 国家 KR

  • 入库时间 2022-08-21 21:24:27

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