Cancer-specific suicide gene expression cassette and adenovirus expression vector comprising the same

摘要

The present invention adenovirus and having telomerase promoter and MMRE, SV40 enhancer associated with tumorigenesis it relates to the use of using the anti-cancer treatment. More specifically , the present invention is its application method telomerase adenovirus vector expressing the suicide gene in tumor -specific promoter having increased by the first activity in more than 90% of the tumor with the activity of telomerase activity is reported that relates to , acting only adenovirus clone Ad-MMRE-hT-TK-enh is a variety of tumors of the present invention and may be useful in cancer gene therapy does not affect the normal cells .