CANCER-SPECIFIC APOPTIN-EXPRESSION CASSETTE AND ADENOVIRUS EXPRESSION VECTOR COMPRISING THE SAME

摘要

invention selectively kill only tumor that ah poptin (apoptin) to increase expression levels of MMRE, imposed by the tumor -specific expression cassette the SV40 enhancer , and the use of using a adenoviral expression vector containing the same , and this anti-cancer treatment . More specifically , the present invention relates to an adenovirus vector and its application MMRE and how much the apoptin protein expressed only in tumor cells increased ability expression of specific tumor destruction in SV40 enhancer , the adenovirus of the present invention Clone Ad-MMRE-apoptin -enh acts only various tumor and may be useful in cancer gene therapy does not affect the normal cells .