BIOMATERIAL CARRIERS OF CYCLODEXTRINS WITH IMPROVED ABSORPTION PROPERTIES AND PROGRESSIVE AND DELAYED RELEASE OF THERAPEUTIC MOLECULES

摘要

The invention relates to a method for preparing a biomaterial comprising at least one bioactive molecule from a basic biomaterial characterized by the following successive operations performed on said basic biomaterial: a) application of a solid mixture of cyclodextrin (s) and / or cyclodextrin derivative (s) and / or inclusion complex (s) of cyclodextrin (s) and / or cyclodextrin derivatives (s), minus a poly (carboxylic acid), and optionally a catalyst, b) heating at a temperature between 100 ° C and 220 ° C for a period of 1 to 60 minutes, c) washing with water; ) drying, and in that at least one bioactive agent is incorporated in the biomaterial, either by impregnating the biomaterial after the drying step in a concentrated solution of bioactive agent, or by using in said solid mixture of inclusion complexes cyclodextrin - bioactive agent prepared beforehand.