PEPTIDE ACTIVATING BOMBESIN-LIKE PEPTIDE RECEPTOR AND UTILIZATION THEREOF

摘要

PPROBLEM TO BE SOLVED: To provide a peptide activating a BRS-3 (bombesin-like peptide receptor sub-type 3), to provide a prophylactic method or a therapeutic method for obesity comprising a step of administering the peptide to the object and to provide a prophylactic agent or a therapeutic agent for the obesity comprising the peptide as an active ingredient. PSOLUTION: A plurality of peptidic ligands containing the minimum activity units considered to activate the BRS-3 are chemically synthesized to study the ability to activate the BRS-3. As a result, the peptide having an amino acid sequence of Leu-Trp-Ala-Cys-Gly-Ser-Phe-Met is found out. The peptide selectively activates the BRS-3. PCOPYRIGHT: (C)2007,JPO&INPIT