Improved recombinant human interferon-beta-1b polypeptide

摘要

The present invention relates to recombinant human interferon-beta-1b ("IFN-beta-1b") polypeptides, or fragments, analogs, derivatives, or variants thereof, having an improved specific activity. The present invention also relates to pharmaceutical compositions comprising such IFN-beta-1b polypeptides, or fragments, analogs, derivatives, or variants thereof, useful for treating multiple sclerosis. The present invention further relates to methods of producing such IFN-beta-1b compositions.