Inorganic antacids containing speed-dispersible granules, and its method of manufacture at the time of use and suspending oral antacids

摘要

PROBLEM TO BE SOLVED: To obtain the subject particles capable of being suspended in an aqueous medium in a short time by dispersing an inorganic antiacid, a sugar alcohol and a disintegrating agent and subsequently spray-drying the suspension. ;SOLUTION: The particles are obtained by homogeneously dispersing an inorganic antiacid (e.g. aluminum hydroxide gel), a sugar alcohol (e.g. mannitol) and a disintegrating agent (e.g. dextrin) in an aqueous medium, and subsequently spray-drying the dispersion. The inorganic antiacid, the sugar alcohol and the disintegrating agent and compounded in amounts of 50-95wt.%, 1-35wt.% and 1-15wt.%, respectively, based on the whole weight of the particles. The particles have large hardness, are hardly pulverized, are easy in storage, can rapidly be dispersed in water, and give mild and non-rough mount touch, since the particles are fine. The particles are convenient for carriage, can rapidly and homogeneously be dispersed and suspended in an aqueous medium, and can orally be administered without giving any uncomfortable touch. The particles are useful for improving the syndromes of digestion acceleration, indigestion, anorexia, gluttony, dull feelings in stomachs, pyrosis, feelings of fullness in stomach and abdomen parts due to indigestion, stomach ache, gastric hyperacidity, etc.;COPYRIGHT: (C)1998,JPO