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Allergenic proteins and peptides from dog dander and uses therefor
Allergenic proteins and peptides from dog dander and uses therefor
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机译:狗皮屑的致敏蛋白和多肽及其用途
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摘要
Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of petides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
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机译:公开了编码<犬类常见犬 I>,Can f I或Can f II过敏原的分离核酸。还描述了编码具有Can f I活性和预计分子量约为19,200道尔顿的肽的cDNA。还公开了编码具有Can f II活性和预计分子量约为18,200道尔顿的肽的cDNA。所述核酸可用作探针以检测样品中Can f I或Can f II核酸的存在或用于重组生产具有Can f I或Can f II活性的肽。具有Can f I或Can f II活性的肽可以用于适合于药物施用的组合物或诊断对狗皮屑的敏感性的方法。
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