Advanced route for the synthesis of cPLA2 inhibitors

摘要

A process for making a compound of formula (I); in which process the compound HC≡C—(CH₂)_n—NH₂ is reacted with the compound R₁—SO₂Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formula; to produce the compound of formula (I), and compounds produced by the process of this invention. The terms R₁, R₂, R₃, R₄ and n have the definitions set forth in the specification.