A141S and G399S mutation in the Omi/HtrA2 protein in Parkinson's disease

摘要

The present invention relates to a method for diagnosing Parkinson's disease in a human being; nucleic acid molecules used in this method; a nucleic acid molecule which encodes a human Omi/HtrA2 protein which has a genetic modification at amino acid position 141 and/or 399 compared with the wild type, and for corresponding segments thereof; a host, preferably a transgenic non-human mammal, into which such a nucleic acid molecule has been introduced; a (poly)peptide which is encoded by such a nucleic acid molecule; a method for finding substances which bind to Omi/HtrA2 protein which is genetically modified compared with the wild type; a substance found with the aid of this method, and a preferably pharmaceutical composition which comprises such a substance. This invention additionally relates to a kit which comprises at least one of the aforementioned nucleic acid molecules.