Substituted pteridines and their use for the preparation of a Medicament for the treatment of inflammatory diseases

摘要

Compounds of polyurethane derivatives for the treatment of respiratory or gastrointestinal diseases or diseases, joints, skin or eye inflammation, peripheral and central nervous system diseases or cancer; And drugs using compounds. First term: a polyphase cyclic compound (1) consisting of 5, 6, or 7 members containing N atoms and other selected atoms of the group consisting of N, S, and O, representing R1, a saturated or unsaturated heterocyclic ring,6 or 7 members that can contain an N atom and another atom selected from the group consisting of N, S and O; R3 a group of the formula a-i in which m 1, 2 or 3 signify; n 0, 1, 2 or 3; R3.1 a radical selected from the group consisting of C1-6 alkyl, C3-6 cycloalkyl, aryl, COOR3.1.1, CONR3.1.1R3.1.2, CN, C1-6 haloalkyl, OR3.1.1, O-C3-6 cycloalkyl , O-C 1-4 alkylene-C3-6 cycloalkyl, O-C 1-4 alkylene-CONH2, O-C 1-4 alkylene-NH2, O-C 1-6 haloalkyl, NR3.1.1R3.1.2, NHCOR3.1.1, SO2R3 .1.1, SO2NR3.1.1R3.1.2, halogen, R3.1.1 H, C1-6 alkyl; R3.1.2 H, C1-6 alkyl; R3.2 a radical selected from the group consisting of C2-6alkyl; C3-6 cycloalkyl, aryl, COOR3.2.1, CONR3.2.1R3.2.3, CN,1.1.2.1.1.1.1.1.1.1.1.1.1.1.1.1.1.2 h, c12-6, r3.2.3 h, C1-6, and their salts, symmetric isomers, dwarfs, racemates, A tolerable hydrate or pharmaceutical solution.